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Words near each other
・ Interleukin 28
・ Interleukin 28 receptor, alpha subunit
・ Interleukin 28B
・ Interleukin 29
・ Interleukin 3
・ Interleukin 30
・ Interleukin 31
・ Interleukin 32
・ Interleukin 33
・ Interleukin 34
・ Interleukin 35
・ Interleukin 36 receptor antagonist
・ Interleukin 37
・ Interleukin 4
・ Interleukin 5
Interleukin 5 receptor alpha subunit
・ Interleukin 6
・ Interleukin 7
・ Interleukin 8
・ Interleukin 8 receptor, alpha
・ Interleukin 8 receptor, beta
・ Interleukin 9
・ Interleukin receptor
・ Interleukin-1 receptor
・ Interleukin-1 receptor family
・ Interleukin-1 receptor-associated kinase
・ Interleukin-1 receptor–associated kinase 4 deficiency
・ Interleukin-10 receptor
・ Interleukin-11 receptor
・ Interleukin-12 receptor


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Interleukin 5 receptor alpha subunit : ウィキペディア英語版
Interleukin 5 receptor alpha subunit

Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA also denotes its human gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3568 )
== Function ==

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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